Use a tool like Rufus or ImgBurn to write the ISO to a CD-R.
Finding a reliable today requires a bit of "digital archaeology." In this guide, we’ll show you how to find the files, create a bootable image, and get it running on modern hardware or virtual machines. Why MS-DOS 6.22? download ms dos 6.22 bootable iso
This allows you to "mount" the entire OS as a single virtual CD. How to Install MS-DOS 6.22 Using the ISO Method A: Virtual Machines (Recommended) Use a tool like Rufus or ImgBurn to write the ISO to a CD-R
Tools like UltraISO , PowerISO , or WinImage allow you to open a bootable disk image. create a bootable image
How to Download and Create an MS-DOS 6.22 Bootable ISO: A Complete Guide