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High-priority topics include COVID-19 and other Coronavirus Infections , Machine Learning and Augmented Intelligence in Clinical Medicine , and Physician Well-Being . This landmark update

Released in July 2025, the continues its seven-decade legacy as the "Bible" of internal medicine. This landmark update, published by McGraw Hill / Medical , represents one of the most comprehensive overhauls in the textbook’s history, integrating cutting-edge science with practical clinical reasoning. Key Features and New Content in the 22nd Edition

Harrison's Principles of Internal Medicine , 22nd Edition: The Definitive Clinical Guide